How to make 99.5%+ CBD ?

The CBD Isolate manufacturing process:

1)Selection of high CBD hemp biomass or hemp flower

2)Drying, processing and decarboxylation of hemp material – ideally 10%+ CBD content

3)Extraction of CBD Oil from hemp – 50%+ CBD Hemp Extract

4)Refinement of CBD oil to remove contaminants – 60%+ Refined CBD Oil

5)Distillation of refined CBD oil to concentrate CBD – 80%+ CBD Distillate

6)Chromatography to purify CBD from distillate 99%+ CBD Isolate

7)Crystallization of CBD to further purify – 99%+ CBD API Manufacture under GMP

We offer 2 methods to refine the CBD extract, one is molecular distillation, and the other is called short path distillation.

For the isolation technology, we use Prep HPLC System to do isolation and purification.

What is Molecular Distillation?

Molecular distillation (Molecular Wiped Film Distillation) is a special kind of liquid - liquid separation technology, which relies on the difference of the average free path of molecular movement of different substances to achieve separation.


Material is delivered from a feed flask into a columniform evaporation section, getting heating, on the outside, (circulating hot fluid jacket type), and a slotted wiper mechanism forcing liquid around and downward in a thin film on the inside.

In the center of the body is a wiped film evaporator with internal cooling condenser, providing a short path for vapor molecules traveling from the heated surface to the condenser surface. For cannabinoids, the internal condenser fluid must be kept elevated (~80°C) to prevent high viscosity or freeze up cbd distillate and the related components. During the itinerary downward, lighter (lower boiling point) fractions of the liquid begin to vaporize, move to the internal condenser and condense, falling down as a liquid into a vessel that catches and separates the distilled liquid (cannabinoid) which flows into a receiver flask. Heavier residue material (chlorophyll, salts, sugars, heavy wax fractions) does not evaporate and instead travels through the still body and flows into a different receiver flask.

What is Short Path Distillation?

Short Path Distillation works in much the same way as (vacuum) steam distillation in that the extract is heated and each compound is then separated because each one has a different boiling point. By heating the distillation flask uniformly and by vacuum pumping, the evaporation flask is brought into a negative pressure state, the boiling point of the solution is reduced, and the evaporation speed is accelerated.

It is especially suitable for the separation and purification of temperature sensitive materials and those compounds that have been thermally decomposed, oxidized or polymerized before the boiling point is reached during atmospheric distillation.

With short path distillation, we could get purity 90%+ CBD.


What is Prep HPLC Technology?

The general objective of preparative chromatography is to isolate, purify and collect your target compounds. Preparative applications are often initially performed on an analytical level and need to be upscaled. Depending on the desired scale, the requirements for a preparative system differ in eluent supply, sample injection, column, and detection. For the CBD/Hemp project, we could use Prep HPLC System to successfully isolate the CBD component. After the HPLC step, the CBD purity can be 99%+.